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Year : 1999  |  Volume : 1  |  Issue : 6  |  Page : 201-208

Physiologic assessment of coronary artery disease in the catheterization laboratory

Center for Coronary Physiology and Imaging, The Division of Cardiovascular Diseases and Department of Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA

Correspondence Address:
Amir Lerman
Mayo Clinic and Foundation, 200 First St. SW Rochester, MN 55905
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Source of Support: None, Conflict of Interest: None

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Coronary artery disease is a progressive process adversely affecting the integrity of the coronary vasculature. In the past years, most studies have focused on the morphological changes leading to compromised coronary blood flow in atherosclerosis. In recent years however, it has become apparent that abnormal coronary vasomotor regulation may precede or accompany gross morphological changes in coronary atherosclerotic disease. In fact, the pathophysiology of angina pectoris in many patients with risk factors for atherosclerosis and minimally obstructive disease may involve abnormal coronary vasomotor regulation. This article will review the current knowledge of the physiologic assessment of both native coronary artery disease and the adequacy of percutaneous coronary interventions.

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