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Year : 2003  |  Volume : 4  |  Issue : 3  |  Page : 4

Cardiac Channelopathies

Institute of Molecular Cardiobiology, The Johns Hopkins University, Baltimore, Maryland, USA

Correspondence Address:
Eduardo Marban
Institute of Molecular Cardiobiology, The Johns Hopkins University, 844Ross Bldg, 720 Rutland Avenue, Baltimore, Maryland 21205
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Source of Support: None, Conflict of Interest: None

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Genetic alterations of various ion channels produce heritable cardiac arrhythmias that predispose affected individuals to sudden death. The investigation of such 'channelopathies' continues to yield remarkable insights into the molecular basis of cardiac excitability. The concept of channelopathies is not restricted to genetic disorders; notably, changes in the expression or post-translational modification of ion channels underlie the fatal arrhythmias associated with heart failure. Recognizing the fundamental defects in channelopathies provides the basis for new strategies of treatment, including tailored pharmacotherapy and gene therapy.

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