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Year : 2007  |  Volume : 8  |  Issue : 1  |  Page : 6-9

Troponin I Levels after coronary bypass operations in Aleppo, Syria

Department of Cardiothoracic Surgery, Al-Salam Hospital, Aleppo, Syria

Correspondence Address:
A Chaikhouni
MD, Sr. Consultant, Cardiology and Cardiovascular Surgery Department, Hamad Medical Corporation, P.O.Box 3050, Doha, Qatar
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Source of Support: None, Conflict of Interest: None

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Background: Biomarkers of myocardial injury are important tools in the diagnosis and management of patients with acute cardiovascular disease. cTnI levels measured 24 hours after cardiac surgery has been reported to be independently predictive of short and long term mortality. Aim : To evaluate the usefulness of cTnI as a marker of myocardial injury after CABG in our laboratory, we measured cTnI level after CABG operation at Al-Salam Hospital in Aleppo, Syria and correlated it with the morbidity and mortality outcome of this operation. Method: Troponin I (cTnI) level was measured after coronary artery bypass grafting operations (CABG) at Al-Salam Hospital in Aleppo, Syria. Consecutive measurements were obtained prospectively in 333 such patients. The patients were divided into two groups: Group I with cTnI level less than 10 ng/ml (256 patients), and Group II with cTnI level more than 10 ng/ml (77 patients). The two groups were similar in all aspects except for significantly more smoking, and more use of IMA graft in group I patients. There was a trend towards using off-pump technique (OPCAB) in Group I patients, but this difference was not statistically significant. Results: Group II patients had significantly higher cardiac (13%) and non-cardiac (12%) complications than group I (4%, and 6.7% respectively). Group II patients also had higher 30 day mortality (6.5%) than group I (0.4%). The higher morbidity and mortality in group II was statistically significant even after adjusting for OPCAB and IMA differences. The sensitivity of cTnI test in our lab was 46%; the specificity 81%; the positive predictive value 31%; the negative predictive value 89%; and the relative risk of cTnI >10 ng/ml was 2.85 . Conclusion: cTnI level is an important predictor of early morbidity and mortality after CABG operation.

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