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Year : 2011  |  Volume : 12  |  Issue : 1  |  Page : 1-6

Smoking effect on ischemic heart disease in young patients

Department of Internal Medicine, Faculty of Medicine, Aleppo University, Aleppo University Heart Hospital, Syria

Correspondence Address:
Khaled Hbejan
Department of Internal Medicine, Faculty of Medicine, Aleppo University, Aleppo University Heart Hospital
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1995-705X.81547

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Objective: To evaluate the effect of tobacco smoking on the risk of nonfatal acute myocardial infarction in young adults (≤45 years). Patient and Methods: We conducted a population-based case-control study with 329 incident acute myocardial infarction cases (42 women; 287 men), consecutively admitted to the Cardiology department of hospitals in Aleppo, Syria, and 778 controls (486 women; 292 men), selected within the noninstitutionalized Aleppo population, during 2008-2010. Odds ratios (OR) and 95% confidence intervals (95%CI) were calculated using unconditional logistic regression. Results: The prevalence of current smoking was 80.8% in male cases and 53.8% in male controls (OR = 3.63, 95%CI: 2.50, 5.27) and 59.5% of female cases were smokers compared with 35.8% of controls (OR = 2.64, 95%CI: 1.39, 5.02). No interaction was found between current smoking and gender on myocardial infarction risk (P = 0.401). A dose-effect response was present, the odds favoring myocardial infarction reaching an eight-fold increase for those who smoked >25 cigarettes/day compared with never smokers. The risk estimate for former smokers was similar to never smokers. Conclusions: Tobacco smoking is an important independent risk factor for acute myocardial infarction in young adults, with similar strength of association for both genders.

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