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ORIGINAL ARTICLE
Year : 2016  |  Volume : 17  |  Issue : 1  |  Page : 13-18

Correlation between diastolic dysfunction and coronary artery disease on coronary computed tomography angiography


1 King Saud bin Abdulaziz, University for Health Sciences; King Abdulaziz Medical City for National Guard - Health Affairs; King Abdulaziz Cardiac Center, Riyadh, Kingdom of Saudi Arabia
2 King Abdulaziz Medical City for National Guard - Health Affairs; King Abdulaziz Cardiac Center, Riyadh, Kingdom of Saudi Arabia
3 King Saud bin Abdulaziz, University for Health Sciences; King Abdulaziz Medical City for National Guard - Health Affairs; King Abdulaziz Cardiac Center; King Abdullah International Medical Research Center, Riyadh, Kingdom of Saudi Arabia

Correspondence Address:
Abdelrahman Jamiel
King Abdulaziz Cardiac Center, King Abdulaziz Medical City for National Guard.Health Affairs, Department Mail Code 1413, P.O. Box. 22490, Riyadh 11426
Kingdom of Saudi Arabia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1995-705X.182649

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Aims: We investigated the relationship between coronary artery calcium score (CACS) and coronary artery disease (CAD) on coronary computed tomography angiography (CCTA), and measures of left ventricular diastolic function (DD). Methods: We included 429 consecutive patients (39% women; mean age 49 ± 12 years) without known CAD, who underwent CCTA and transthoracic echocardiography (TTE) within 1-month. Evaluation of CCTA was per vessel, and per segment basis for intraluminal diameter stenosis. We also used the 16-segment model to determine overall coronary plaque burden with segment involvement score (SIS). DD on TTE was assessed using mitral inflow E wave-to-A wave ratio (EAR) and tissue Doppler early mitral annual tissue velocity axial excursion. Results: A total of 293 (68.4%) patients had DD, 15.4% had more than stage 2 DD. The presence of DD was associated with increasing CACS (P < 0.001). Similarly, there was a statistically significant correlation between EAR and CCS (r = −0.147, P = 0.004) and SIS (r = 0.536, P < 0.001). The prevalence of more than stage 2 DD was associated with higher prevalence of obstructive CAD (26.2% vs. 11.7%, P < 0.0001). In multivariable analyses, the independent predictors of more than stage 1 DD are the age (P < 0.001), and diabetes (P = 0.010), while the CACS and SIS were not independently associated with DD. Conclusion: Our analysis suggests that CACS, as well as CAD by CCTA, are not independently associated with measures of DD on echocardiography.


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