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Year : 2018  |  Volume : 19  |  Issue : 3  |  Page : 85-87

Study of nickel levels in patients with atrial septal defect undergoing amplatzer device closure

1 Department of Cardiology, Dhanalakshmi Srinivasan Medical College and Hospital, Perambalur, Tamil Nadu, India
2 Department of Pediatrics, Dhanalakshmi Srinivasan Medical College and Hospital, Perambalur, Tamil Nadu, India
3 Department of Cardiology, Grant Medical College, Sir JJ Group of Hospitals, Mumbai, Maharashtra, India

Correspondence Address:
Dr. Ganesh Narayana
Department of Cardiology, Dhanalakshmi Srinivasan Medical College and Hospital, Perambalur - 621 212, Tamil Nadu
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Source of Support: None, Conflict of Interest: None


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Transcatheter closure of atrial septal defects (ASDs) using nickel titanium Naval Ordnance Laboratory (Nitinol)-containing devices (Amplatzer, AGA Medical, Golden Valley, Minnetosa) is being widely practiced. Controversies still exist regarding the release of nickel from these devices and the allergy and other ill effects of nickel and also the duration of antiplatelet therapy to aid endothelization of the device. Objective: To study the nickel levels in patients who underwent ASD closure with platinum-coated Nitinol-containing Amplatzer septal occluder. Methodology: A prospective study was conducted on 25 patients, between 6 years and 40 years of age who underwent ASD closure with Amplatzer septal occlude sizes ranging from 12 to 36 mm from January 2009 to January 2010. Blood nickel levels were estimated using atomic absorption photometry before and 24 h after the procedure and later at 1 month, 3 months, and 6 months postprocedure. A value of <2 mcg/dl was considered to be normal. Statistical analysis was performed by the use of the Wilcoxon test. Results: The blood nickel levels at mean baseline, 24 h, 1 month, 3 months, and 6 months postprocedure were 1.05, 1.39, 0.98, 0.79, and 0.74 (mcg/dl), respectively. Conclusions: Percutaneous ASD closure using Nitinol devices can be carried out safely without any significant ill effects related to nickel release.

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