Login | Users Online: 1722  
Home Print this page Email this page Small font sizeDefault font sizeIncrease font size   
Home | About us | Editorial board | Search | Ahead of print | Current Issue | Archives | Submit article | Instructions | Subscribe | Advertise | Contact us
Year : 2023  |  Volume : 24  |  Issue : 2  |  Page : 98-103

Left ventricular global longitudinal strain following acute ST-elevation myocardial infarction – A comparison of primary coronary angioplasty and tenecteplase-based pharmacological reperfusion strategy

1 Department of Cardiology, Dubai Health Authority, Dubai Hospital, Dubai, UAE
2 Department of Cardiology, The Ministry of Health and Prevention, Fujairah Hospital, Fujairah, UAE
3 Department of Cardiology, Dubai Health Authority, Dubai Hospital, Dubai, UAE; Department of Cardiology, Faculty of Medicine, Tanta University, Tanta, Egypt

Correspondence Address:
Dr. Mosaad Abushabana
Department of Cardiology, Dubai Hospital, Al Khaleej Street, Al Baraha, P. O. Box 7272, Dubai
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/heartviews.heartviews_103_22

Rights and Permissions

Objective: In the setting of acute ST-elevation myocardial infarction (STEMI), reperfusion therapy with primary percutaneous coronary intervention (PCI) performed by an experienced team or pharmacological reperfusion with thrombolytic therapy is highly recommended. Standard echocardiographic measurement of the left ventricular ejection fraction (LVEF) is widely used to assess left ventricular global systolic function. This study was designed to compare the assessment of global left ventricular function by standard LVEF and global longitudinal strain (GLS) in the two well-known reperfusion strategies. Materials and Methods: We conducted a retrospective single-center observational study in 50 patients with acute STEMI who underwent primary PCI (n = 25) and Tenecteplase (TNK)-based pharmacological reperfusion therapy (n = 25). The primary outcome was left ventricle (LV) systolic function after primary PCI, as assessed by two-dimensional (2D) GLS using speckle-tracking echocardiography (STE), as well as LVEF using standard 2D echocardiogram using Simpson's biplane method. Results: Overall mean age was 53.7 ± 6.9 years with 88% male gender. The mean door-to-needle time was 29.8 ± 4.2 min in the TNK-based pharmacological reperfusion therapy arm, and the mean door-to-balloon time was 72.9 ± 15.4 min in the primary PCI arm. LV systolic function was significantly better in the primary PCI arm as compared to the TNK-based pharmacological reperfusion therapy, both by 2D STE (mean GLS: −13.6 ± 1.4 vs. −10.3 ± 1.2, P ≤ 0.001) and LVEF (mean LVEF: 42.2 ± 2.9 vs. 39.9 ± 2.7, P = 0.006). There were no significant differences in mortality and inhospital complications in both groups. Conclusion: Global LV systolic function is significantly better after primary coronary angioplasty as compared to TNK-based pharmacological reperfusion therapy when assessed by routine LVEF and 2D GLS in the setting of acute STEMI.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded30    
    Comments [Add]    

Recommend this journal