| REVIEW ARTICLE |
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| Year : 2023 | Volume
: 24
| Issue : 4 | Page : 201-207 |
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A new era of clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 gene editing technology in cardiovascular diseases: Opportunities, challenges, and perspectives
Kumar Rahul1, Sushil Kumar Singh1, Sarvesh Kumar1, Vivek Tewarson1, Mohammad Zeeshan Hakim1, Karan Kaushik2, Satish Kumar3, Bhupendra Kumar1
1 Department of Cardiovascular and Thoracic Surgery, King George's Medical University, Lucknow, Uttar Pradesh, India
2 Department of Cardiac Anaesthesiology, King George's Medical University, Lucknow, Uttar Pradesh, India
3 Department of Internal Medicine, King George's Medical University, Lucknow, Uttar Pradesh, India
Correspondence Address:
Dr. Kumar Rahul
Department of Cardiovascular and Thoracic Surgery, King George's Medical University, Shahmina Road, Lucknow - 226 003, Uttar Pradesh
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/heartviews.heartviews_49_23
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Cardiovascular diseases (CVDs) remain major causes of global mortality in the world. Genetic approaches have succeeded in the discovery of the molecular basis of an increasing number of cardiac diseases. Genome-editing strategies are one of the most effective methods for assisting therapeutic approaches. Potential therapeutic methods of correcting disease-causing mutations or of knocking out specific genes as approaches for the prevention of CVDs have gained substantial attention using genome-editing techniques. Recently, the clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR/Cas9) system has become the most widely used genome-editing technology in molecular biology due to its benefits such as simple design, high efficiency, good repeatability, short cycle, and cost-effectiveness. In the present review, we discuss the possibilities of applying the CRISPR/Cas9 genome-editing tool in the CVDs.
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